Farnesyltransferase inhibitors: recent advances
Authors: Huang, Chia-Yu; Rokosz, Laura
Source: Expert Opinion on Therapeutic Patents, Volume 14, Number 2, 1 February 2004 , pp. 175-186(12)
Publisher: Informa Healthcare
Abstract:Farnesyltransferase inhibitors (FTIs) represent a promising new approach for the treatment of cancer. Although the exact mechanism of action of these compounds is not fully understood, several compounds have progressed into clinical trials with proven efficacy. This review will describe the recent patents (2000 to present) that cover FTIs in the clinic, together with other classes that are still under development.
Document Type: Review Article
Publication date: February 1, 2004