Cardiac sodium channels and inherited electrophysiologic disorders: a pharmacogenetic overview

Authors: Smits, Jeroen PP; Blom, Marieke T; Wilde, Arthur AM; Tan, Hanno L

Source: Expert Opinion on Pharmacotherapy, Volume 9, Number 4, March 2008 , pp. 537-549(13)

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Abstract:

Sodium (Na) channels are essential for cardiac electrical activity. Cardiac Na channel dysfunction, inherited or acquired, can induce life-threatening conduction and arrhythmia disorders. Inherited Na channel dysfunction may put affected patients at a greater risk for these complications when channel-modifying drugs are prescribed. This study addressed pharmacogenetic effects in three well-described Na channel-related diseases: long QT syndrome type 3, Brugada syndrome and inherited cardiac conduction disease. A review of the currently available literature on cardiac Na channel-modulating drugs was undertaken. An overview is given of the known risks of development of the previously mentioned complications of commonly prescribed drugs in patients affected with Na channel-related diseases and the underlying mechanisms.

Keywords: Brugada syndrome; cardiac arrhythmia syndromes; conduction disease; inherited; long QT syndrome type 3; pharmacogenomics; sodium channel

Document Type: Research article

DOI: http://dx.doi.org/10.1517/14656566.9.4.537

Publication date: 2008-03-01

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