Review of azelastine nasal spray in the treatment of allergic and non-allergic rhinitis
Authors: Lee, Christina1; Corren, Jonathan2
Source: Expert Opinion on Pharmacotherapy, Volume 8, Number 5, April 2007 , pp. 701-709(9)
Publisher: Informa Healthcare
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Abstract:
Azelastine is a potent H1-antihistamine, which is available as a topical nasal spray and indicated for both seasonal allergic and non-allergic vasomotor rhinitis. In addition to its antihistaminic effects, it has also been shown to have a number of other potentially important attributes, including effects on cytokines, adhesion molecules and inflammatory cells. Azelastine nasal spray has been shown to benefit patients who have not responded adequately to loratadine and fexofenadine, and is significantly more efficacious than cetirizine and levocabastine in patients with seasonal allergic rhinitis. Given its unique pharmacologic properties and clinical profile, azelastine maintains an important role in the treatment of chronic rhinitis.Keywords: allergic rhinitis; azelastine hydrochloride; non-allergic rhinitis
Document Type: Drug Evaluation
DOI: 10.1517/14656566.8.5.701
Affiliations: 1: 1Research Physician, Department of Medicine, Division of Pulmonary and Critical Care Medicine, Section of Clinical Immunology and Allergy, University of California, Los Angeles and Allergy Research Foundation, Los Angeles, CA, USA 2: 2Medical Director and Associate Clinical Professor of Medicine, Department of Medicine, Division of Pulmonary and Critical Care Medicine, Section of Clinical Immunology and Allergy, University of California, Los Angeles and Allergy Research Found
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