Authors: Nabholtz, Jean-Marc; Gligorov, Joseph

Source: Expert Opinion on Pharmacotherapy, Volume 6, Number 7, 1 June 2005 , pp. 1073-1094(22)

Publisher: Informa Healthcare

Abstract:

Among the novel chemotherapeutic agents introduced in the last decade, the taxanes have emerged as the most powerful group of compounds, and results available so far confirm that they will be remembered in the future as the breast c-ancer chemotherapy of the 1990s. Two taxanes are available (paclitaxel and docetaxel) and they share some characteristics, although they do have some significant differences both in terms of their preclinical profile and, most importantly, their clinical characteristics. There are three main clinical differences: different e-fficacy–toxicity ratio in relation to dose and schedule; different integr-ability in anthracycline- and taxane-containing regimens, secondary to differences in pharmacokinetic interactions with anthracyclines; and different level of synergism between each taxane and trastuzumab. In clinical practice, the t-axanes are now standard therapy in metastatic breast cancer. Their role as monochemotherapy or in combination with anthracyclines in advanced breast cancer has suggested their potential therapeutic impact in the t-reatment of patients with early breast cancer. Recent results in the adjuvant s-etting show that taxanes, used either in combination or in sequential t-herapy, possess the capability to induce significant improvements, in part-icular in terms of survival; thus confirming the positive impact of taxanes on the natural history of breast cancer. However, further results of all completed or ongoing Phase III trials in the early setting will help define the optimal use of t-axanes and maximise the induced benefits for breast cancer patients.

Keywords: adjuvant; anthracyclines; breast cancer; capecitabine; docetaxel; gemcitabine; metastatic; paclitaxel; platinum salts; taxanes

Document Type: Review article

DOI: http://dx.doi.org/10.1517/14656566.6.7.1073

Publication date: 2005-06-01

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