PDE5 inhibitors for cystic fibrosis: can they also enhance chloride transport?

Author: Antoniu, Sabina A

Source: Expert Opinion on Investigational Drugs, Volume 17, Number 6, June 2008 , pp. 965-968(4)

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Abstract:

Background: Many compounds are currently under investigation for cystic fibrosis (CF), a genetic disorder caused by various mutations in cystic fibrosis transmembrane regulator (CFTR). Objective: To evaluate a preclinical study on the effects of sildenafil and vardenafil, two PDE5 inhibitors, on ion transport in CF animal models. Methods/results: The effects of sildenafil and vardenafil on chloride and sodium conductance were assessed in both ΔF508CFTR and CFTR knockout mice models. They improved chloride transport in the ΔF508CFTR model and had no effects in the CFTR knockout model. Conclusion: Sildenafil and vardenafil are promising agents for CF therapy provided they also demonstrate clinical efficacy.

Keywords: animal models; cystic fibrosis; sildenafil; vardenafil

Document Type: Research article

DOI: http://dx.doi.org/10.1517/13543784.17.6.965

Affiliations: 1: Assistant Lecturer `Gr T Popa' University of Medicine and Pharmacy Iasi, Pulmonary Disease University Hospital, Division of Pulmonary Disease, 30 Dr I Cihac Street, 700115 Iasi, Romania +40 232 265 633; +40 232 265 633; sabina.antonela.antoniu@pneum. umfiasi.ro

Publication date: 2008-06-01

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