Safety of peginterferon in the treatment of chronic hepatitis C
Authors: Hashemi, Nikroo; Rossi, Simona; Navarro, Victor J; Herrine, Steven K
Source: Expert Opinion on Drug Safety, Volume 7, Number 6, November 2008 , pp. 771-781(11)
Publisher: Informa Healthcare
Abstract:Background: Combination of ‘pegylated’ interferons (IFNs) plus ribavirin, the standard treatment of chronic hepatitis C (CHC), is frequently associated with side effects. Anticipation, recognition and proper management of these side effects are important to ensure compliance with therapy and achievement of sustained virologic response. Objective: To illustrate the side effect profile of pegIFN-α in the treatment of CHC. Methods: Studies and abstracts were identified through a computerized, English language literature search. Key search terms included peginterferon and CHC. Information available only in abstract form was retrieved from national and international hepatology associations. Results: Most adverse events occurring with combination therapy can be anticipated and managed appropriately; therefore, premature discontinuation of therapy owing to side effects is not required in most patients.
Document Type: Research Article
Publication date: November 1, 2008