Authors: Eckman, Ari; Dobs, Adrian
Source: Expert Opinion on Drug Safety, Volume 7, Number 6, November 2008 , pp. 691-702(12)
Publisher: Informa Healthcare
Abstract:Gynecomastia is caused by drugs in 10 – 25% of all cases. The pathophysiologic mechanism for some drugs includes exogenous estrogens exposure, medications that cause hypogonadism, anti-androgenic effects and hyperprolactinemia. This manuscript reviews common examples of drug-induced gynecomastia, discussing the mechanisms and possible treatments. Discontinuing the medication is always the best choice; however, if this is not possible, then testosterone replacement therapy may be needed for hypogonadism. When a man is euogonadal, a trial of the anti-estrogen, tamoxifen or an aromatase inhibitor may be an option.
Document Type: Research Article
Publication date: November 1, 2008