The epidemiology of drug-induced disorders: the kidney
Authors: Taber, Stephanie S; Pasko, Deborah A
Source: Expert Opinion on Drug Safety, Volume 7, Number 6, November 2008 , pp. 679-690(12)
Publisher: Informa Healthcare
Abstract:The epidemiology of drug-induced renal disorders is a complex topic. Drug-associated nephrotoxicity accounts for 18 – 27% of all acute kidney injury cases in US hospitals. Medications can affect all aspects of the kidney, and drugs that are associated with renal dysfunction are used commonly in clinical practice. The article reviews six major mechanisms of drug-induced renal dysfunction as well as lists the major medications involved. NSAIDs, aminoglycosides, amphotericin B and calcineurin inhibitors are just some examples of drugs that contribute to renal dysfunction. The medical community must be aware of patient risk factors for nephrotoxicity, as well as the drug's inherent nephrotoxic potential, when prescribing and administering medications.
Document Type: Research Article
Publication date: November 2008