Neuroleptic malignant syndrome induced by atypical antipsychotics

Author: Farver D.K.

Source: Expert Opinion on Drug Safety, Volume 2, Number 1, 1 January 2003 , pp. 21-35(15)

Publisher: Informa Healthcare

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Abstract:

A review of the English literature confirms that neuroleptic malignant syndrome (NMS) occurs with both traditional and atypical antipsychotic medications. Published reports of NMS induced by the traditional antipsychotics have given the practitioner valuable information on the prevention and treatment of this adverse effect. Case reports have also been published concerning NMS and clozapine, risperidone, olanzapine and quetiapine. By evaluating the case reports of atypical antipsychotic-induced NMS, valuable information may be obtained concerning similarities or differences from that induced by the traditional antipsychotics. The case reports of NMS with atypical antipsychotics were evaluated for diagnosis, age/sex of patient, risk factors, antipsychotic doses and duration of use, symptoms of NMS, and clinical course.

Keywords: atypical antipsychotics; clozapine; neuroleptic malignant syndrome (NMS); olanzapine; quetiapine; risperidone; ziprasidone

Document Type: Review article

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