Liposomal antibiotics for the treatment of infectious diseases
Source: Expert Opinion on Drug Delivery, Volume 10, Number 11, November 2013 , pp. 1515-1532(18)
Publisher: Informa Healthcare
Abstract:Introduction: Liposomal delivery systems have been utilized in developing effective therapeutics against cancer and targeting microorganisms in and out of host cells and within biofilm community. The most attractive feature of liposome-based drugs are enhancing therapeutic index of the new or existing drugs while minimizing their adverse effects.
Areas covered: This communication provides an overview on several aspects of liposomal antibiotics including the most widely used preparation techniques for encapsulating different agents and the most important characteristic parameters applied for examining shape, size and stability of the spherical vesicles. In addition, the routes of administration, liposome–cell interactions and host parameters affecting the biodistribution of liposomes are highlighted.
Expert opinion: Liposomes are safe and suitable for delivery of variety of molecules and drugs in biomedical research and medicine. They are known to improve the therapeutic index of encapsulated agents and reduce drug toxicity. Recent studies on liposomal formulation of chemotherapeutic and bioactive agents and their targeted delivery show liposomal antibiotics potential in the treatment of microbial infections.
Document Type: Research Article
Affiliations: 1: 1 Laurentian University, The Novel Drug & Vaccine Delivery Systems Facility, Department of Chemistry and Biochemistry, Sudbury, ON, P3E 2C6, Canada +1 705 675 1151 ext. 2190; +1 705675 4844;, Email: firstname.lastname@example.org 2: 2 University of Texas at Tyler, Department of Biology, Tyler, TX, USA
Publication date: November 1, 2013