Polypeptides and polyaminoacids in drug delivery
Source: Expert Opinion on Drug Delivery, Volume 9, Number 2, February 2012 , pp. 183-201(19)
Publisher: Informa Healthcare
Abstract:Introduction: Advances achieved over the last few years in drug delivery have provided novel and versatile possibilities for the treatment of various diseases. Among the biomaterials applied in this field, it is worth highlighting the increasing importance of polyaminoacids and polypeptides. The appealing properties of these polymers are very promising for the design of novel compositions in a variety of drug delivery applications.
Areas covered: This review provides an overview on the general characteristics of polyaminoacids and polypeptides and briefly discusses different synthetic pathways for their production. This is followed by a detailed description of different drug delivery applications of these polymers, emphasizing those examples that already reached advanced preclinical development or have entered clinical trials.
Expert opinion: Polyaminoacids and polypeptides are gaining much attention in drug delivery due to their exceptional properties. Their application as polymers for drug delivery purposes has been sped up by the significant achievements related to their synthesis. Certainly, cancer therapy has benefited the most from these advances, although other fields such as vaccine delivery and alternative administration routes are also being successfully explored. The design of new entities based on polyaminoacids and polypeptides and the improved insight gained in drug delivery guarantee exciting findings in the near future.
Document Type: Research Article
Affiliations: 1: 3 University of Santiago de Compostela, Department of Organic Chemistry and Center for Research in Biological Chemistry and Molecular Materials (CIQUS), Jenaro de la Fuente s/n, 15782 Santiago de Compostela, Spain 2: 1 University of Santiago de Compostela, School of Pharmacy, Department of Pharmacy and Pharmaceutical Technology, 15782 Santiago de Compostela, Spain ++34 981 594488 ext 15252; ++34 981 547148;, Email: firstname.lastname@example.org
Publication date: 2012-02-01