Authors: Shukla, Dali¹; Chakraborty, Subhashis²; Mishra, Brahmeshwar¹

Source: Expert Opinion on Drug Delivery, Volume 9, Number 1, January 2012 , pp. 9-18(10)

Publisher: Informa Healthcare

Abstract:

Objective: The present work was undertaken with an objective to design a multilayered dosage form of doxofylline, using pastillation technology, for the chronotherapeutic management of nocturnal asthma.

Research design & methods: Pastilles consisting of the drug, polyethylene glycol and colloidal silicon dioxide, were generated using an in-house laboratory-scale pastillation device. The pastilles were further coated with enteric polymers and a floating layer, using conventional coater. The pastilles were subjected to physicochemical analysis, morphological characterization, In vitro drug release studies and in vivo pharmacokinetic studies in rats.

Results: It was observed that colloidal silicon dioxide was instrumental in improving the contact angle of the pastilles. The uncoated pastilles released the drug immediately, while the enteric-coated (10% w/w) pastilles were found to have sufficient acid resistance when the coat is applied with 5% (v/v) triethyl citrate as plasticizer. The in vivo blood serum profile indicated that the pastilles coated with the enteric coat and the additional floating coat were effective in significantly delaying the in vivo drug release required for the chronotherapeutic treatment of nocturnal asthma.

Conclusion: The present work opens a new alternative to the conventional tablet or capsule dosage form for the development of both immediate-release and modified-release drug delivery systems.

Keywords: chronotherapeutic management; doxofylline; enteric coating; nocturnal asthma; pastillation

Document Type: Research article

DOI: http://dx.doi.org/10.1517/17425247.2012.638915

Affiliations: 1: 1 Banaras Hindu University, Institute of Technology, Department of Pharmaceutics, Varanasi, 221005, India ++915426702748; ++91 542 2368428;, Email: bmishrabhu@rediffmail.com 2: 2 Evonik Degussa India Pvt. Ltd, Krislon House, Sakivihar Road, Andheri East, Mumbai, 400072, India

Publication date: 2012-01-01

More about this publication?

• Editorial Board
• Information for Authors
• Subscribe to this Title
• Terms & Conditions
• ingentaconnect is not responsible for the content or availability of external websites

Related content

• In this: publication
• By this: publisher
• In this Subject: Pharmacology
• By this author: Shukla, Dali ;  Chakraborty, Subhashis ;  Mishra, Brahmeshwar

Website © Publishing Technology. Article copyright remains with the publisher, society or author(s) as specified within the article.

• Terms and conditions
• Privacy policy
• Information for advertisers