Lipid and polymeric carrier-mediated nucleic acid delivery

Authors: Zhu, Lin1; Mahato, Ram I2

Source: Expert Opinion on Drug Delivery, Volume 7, Number 10, October 2010 , pp. 1209-1226(18)

Publisher: Informa Healthcare

Buy & download fulltext article:

OR

Price: $99.00 plus tax (Refund Policy)

Abstract:

Importance of the field: Nucleic acids such as plasmid DNA, antisense oligonucleotide, and RNA interference (RNAi) molecules, have a great potential to be used as therapeutics for the treatment of various genetic and acquired diseases. To design a successful nucleic acid delivery system, the pharmacological effect of nucleic acids, the physiological condition of the subjects or sites, and the physicochemical properties of nucleic acid and carriers have to be thoroughly examined.

Areas covered in this review: The commonly used lipids, polymers and corresponding delivery systems are reviewed in terms of their characteristics, applications, advantages and limitations.

What the reader will gain: This article aims to provide an overview of biological barriers and strategies to overcome these barriers by properly designing effective synthetic carriers for nucleic acid delivery.

Take home message: A thorough understanding of biological barriers and the structure–activity relationship of lipid and polymeric carriers is the key for effective nucleic acid therapy.

Keywords: lipid; liposomes; non-viral gene delivery; nucleic acid; oligonucleotides; polymer; siRNA

Document Type: Research Article

DOI: http://dx.doi.org/10.1517/17425247.2010.513969

Affiliations: 1: 2University of Tennessee Health Science Center, Department of Pharmaceutical Sciences, 19 South Manassas St, Cancer Research Building RM 226, Memphis, TN 38103, USA 2: 1University of Tennessee Health Science Center, Department of Pharmaceutical Sciences, 19 South Manassas St, Cancer Research Building RM 226, Memphis, TN 38103, USA +1 901 448 6929; +1 901 448 2099;, Email: rmahato@uthsc.edu

Publication date: October 1, 2010

More about this publication?
Related content

Key

Free Content
Free content
New Content
New content
Open Access Content
Open access content
Subscribed Content
Subscribed content
Free Trial Content
Free trial content

Text size:

A | A | A | A
Share this item with others: These icons link to social bookmarking sites where readers can share and discover new web pages. print icon Print this page