Systemic delivery of therapeutics to neuronal tissues: a barrier modulation approach
Authors: Campbell, Matthew; Ozaki, Ema; Humphries, Peter
Source: Expert Opinion on Drug Delivery, Volume 7, Number 7, July 2010 , pp. 859-869(11)
Publisher: Informa Healthcare
Abstract:Importance of the field: Efficient systemic delivery of low-molecular-mass therapeutics to neuronal tissue remains a central issue not only to drug development but also to the chronic treatment of a range of neurodegenerative disorders.
Areas covered in this review: This review discusses the potential of using RNA interference to modulate tight junction proteins at the blood–brain barrier and inner blood–retina barrier. Both systemic delivery of short-interfering RNA and viral-mediated delivery of short hairpin RNA are discussed, highlighting the therapeutic area relevant to each.
What the reader will gain: Readers will gain an insight into the potential of size-selective and reversible modulation of neuronal barriers and the types of low-molecular-mass molecule that could be used in the treatment of various neurodegenerative or neuromalignant disorders.
Take home message: The purpose of this review is to describe a new therapeutic strategy for systemic delivery of low-molecular-mass therapeutics to neuronal tissues.
Document Type: Research Article
Affiliations: Smurfit Institute of Genetics, Trinity College Dublin, Ocular Genetics Unit, Dublin 2, Ireland +353 1 8962164; +353 1 8963848;, Email: Matthew.Campbell@tcd.ie
Publication date: July 1, 2010