Authors: Alvarez-Lorenzo, Carmen¹; Bucio, Emilio²; Burillo, Guillermina²; Concheiro, Angel¹

Source: Expert Opinion on Drug Delivery, Volume 7, Number 2, February 2010 , pp. 173-185(13)

Publisher: Informa Healthcare

Abstract:

Importance of the field: Medical devices with the capability of hosting drugs are being sought for prophylaxis and treatment of inflammatory response and microbial colonization and proliferation that are associated with their use.

Areas covered in this review: This review analyzes the interest of γ-ray irradiation for providing medical devices with surfaces able to load drugs and to deliver them in a controlled way. The papers published in the last 20 years on the subject of γ-ray irradiation methods for surface functionalization of polymers and their application for developing medicated medical devices are discussed.

What the reader will gain: The information reported may help to gain insight to the state-of-the-art of γ-ray irradiation approaches and their current advantages/limitations for tailoring the surface of medical devices to fit preventive and curative demands.

Take home message: Grafting of polymer chains able to establish specific interactions with the drug, grafting of stimuli-responsive networks that regulate drug diffusion through the hydrogel-type surface as a function of the surrounding conditions, and grafting of cyclodextrins that control uptake and delivery through the affinity constant of inclusion complexes have been revealed as efficient approaches for endowing medical devices with the capability of also acting as drug delivery systems.

Keywords: anti-inflammatory drug; antimicrobial surface; drug delivery; gamma-ray grafting; grafted cyclodextrin; medical device; stimuli-responsive polymer

Document Type: Research article

DOI: http://dx.doi.org/10.1517/17425240903483174

Affiliations: 1: 1Universidad de Santiago de Compostela, Departamento de Farmacia y Tecnología Farmacéutica, 15782-Santiago de Compostela, Spain +34981563100; +34981547148;, Email: angel.concheiro@usc.es 2: 2Universidad Nacional Autónoma de México, Instituto de Ciencias Nucleares, Departamento de Química de Radiaciones y Radioquímica, Circuito Exterior, Ciudad Universitaria, México DF 04510, México

Publication date: 2010-02-01

More about this publication?

• Editorial Board
• Information for Authors
• Subscribe to this Title
• Terms & Conditions
• ingentaconnect is not responsible for the content or availability of external websites

Related content

• In this: publication
• By this: publisher
• In this Subject: Pharmacology
• By this author: Alvarez-Lorenzo, Carmen ;  Bucio, Emilio ;  Burillo, Guillermina ;  Concheiro, Angel

Website © Publishing Technology. Article copyright remains with the publisher, society or author(s) as specified within the article.

• Terms and conditions
• Privacy policy
• Information for advertisers