Controlled release using mesoporous materials containing gate-like scaffoldings

Authors: Aznar, Elena; Martínez-Máñez, Ramón; Sancenón, Félix

Source: Expert Opinion on Drug Delivery, Volume 6, Number 6, June 2009 , pp. 643-655(13)

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Abstract:

The use of gated mesoporous silica solids as suitable systems for controlled-release protocols is reviewed. These materials are based on mesoporous silica supports that can be prepared with tailor-made pores of around 2 - 10 nm and that show a very large specific surface area (up to 1200 m²/g), thus having a large load capacity. The solids can be additionally functionalised in the external surface with gate-like systems that can be opened on command to allow cargo release. Light, redox reactions, pH, temperature, polarity and enzyme-driven protocols are shown. The possible application in drug delivery protocols is discussed.

Keywords: controlled delivery; gate-like scaffoldings; hybrid materials; mesoporous silica

Document Type: Research article

DOI: http://dx.doi.org/10.1517/17425240902895980

Publication date: 2009-06-01

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