Polymeric carriers: role of geometry in drug delivery

Authors: Simone, Eric A; Dziubla, Thomas D; Muzykantov, Vladimir R

Source: Expert Opinion on Drug Delivery, Volume 5, Number 12, December 2008 , pp. 1283-1300(18)

Publisher: Informa Healthcare

Buy & download fulltext article:


Price: $99.00 plus tax (Refund Policy)


The unique properties of synthetic nanostructures promise a diverse set of applications as carriers for drug delivery, which are advantageous in terms of biocompatibility, pharmacokinetics, targeting and controlled drug release. Historically, more traditional drug delivery systems have focused on spherical carriers. However, there is a growing interest in pursuing non-spherical carriers, such as elongated or filamentous morphologies, now available due to novel formulation strategies. Unique physiochemical properties of these supramolecular structures offer distinct advantages as drug delivery systems. In particular, results of recent studies in cell cultures and lab animals indicate that rational design of carriers of a given geometry (size and shape) offers an unprecedented control of their longevity in circulation and targeting to selected cellular and subcellular locations. This article reviews drug delivery aspects of non-spherical drug delivery systems, including material selection and formulation, drug loading and release, biocompatibility, circulation behavior, targeting and subcellular addressing.

Keywords: Formulation; geometry; micelle; nano; polymer

Document Type: Research Article

DOI: http://dx.doi.org/10.1517/17425240802567846

Publication date: December 1, 2008

More about this publication?
Related content


Free Content
Free content
New Content
New content
Open Access Content
Open access content
Subscribed Content
Subscribed content
Free Trial Content
Free trial content

Text size:

A | A | A | A
Share this item with others: These icons link to social bookmarking sites where readers can share and discover new web pages. print icon Print this page