Authors: Raucher, Drazen; Massodi, Iqbal; Bidwell, Gene L

Source: Expert Opinion on Drug Delivery, Volume 5, Number 3, March 2008 , pp. 353-369(17)

Publisher: Informa Healthcare

Abstract:

Current chemotherapy treatment of solid tumors is limited due to a lack of specific delivery of the drugs to the tumor, leading to systemic toxicity. Therefore, it is necessary to develop targeted cancer therapies and tumor-targeted drug carriers. The authors review the development of elastin-like polypeptide (ELP) as a potential carrier for thermally targeted delivery of therapeutics. The authors searched Medline for articles concerning the application of ELP as a drug delivery vector for small molecule drugs and therapeutic peptides. ELP has been demonstrated to be a promising thermally targeted carrier. Further examination of the in vivo biodistribution and efficacy will provide the necessary data to advance ELP technology toward the ultimate goal of human therapeutics.

Keywords: c-Myc; doxorubicin; elastin-like polypeptide; p21; therapeutic peptides; thermal targeting

Document Type: Research article

DOI: http://dx.doi.org/10.1517/17425247.5.3.353

Publication date: 2008-03-01

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