Liposomal nanomedicines

Authors: Fenske, David B1; Cullis, Pieter R2

Source: Expert Opinion on Drug Delivery, Volume 5, Number 1, January 2008 , pp. 25-44(20)

Publisher: Informa Healthcare

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Abstract:

Liposomal nanoparticles (LNs) encapsulating therapeutic agents, or liposomal nanomedicines, represent an advanced class of drug delivery systems, with several formulations presently on the market and many more in clinical trials. Over the past 20 years, a variety of techniques have been developed for encapsulating both conventional drugs (such as anticancer drugs and antibiotics) and the new genetic drugs (plasmid DNA containing therapeutic genes, antisense oligonucleotides and small interfering RNA) within LNs. If the LNs possess certain properties, they tend to accumulate at sites of disease, such as tumours, where the endothelial layer is ‘leaky’ and allows extravasation of particles with small diameters. These properties include a diameter centred on 100 nm, a high drug-to-lipid ratio, excellent retention of the encapsulated drug, and a long (> 6 h) circulation lifetime. These properties permit the LNs to protect their contents during circulation, prevent contact with healthy tissues, and accumulate at sites of disease. The authors discuss recent advances in this field involving conventional anticancer drugs, as well as applications involving gene delivery, stimulation of the immune system and silencing of unwanted gene expression. Liposomal nanomedicines have the potential to offer new treatments in such areas as cancer therapy, vaccine development and cholesterol management.

Keywords: antisense oligonucleotides; drug delivery; enhanced permeation and retention; gene therapy; liposomal nanoparticles; siRNA

Document Type: Research Article

DOI: http://dx.doi.org/10.1517/17425247.5.1.25

Affiliations: 1: 1University College of the Fraser Valley, Department of Chemistry, 33844 King Road, Abbotsford, BC, V2S 7M8, Canada, Email: david.fenske@ucfv.ca 2: 2University of British Columbia, Centre for Drug Research and Development, Department of Biochemistry and Molecular iology, Life Sciences Centre, 2350 Health Sciences Mall, Vancouver, BC, V6T 1Z3, Canada

Publication date: January 1, 2008

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