Design of nanoparticle-based dry powder pulmonary vaccines

Authors: Pulliam, Brian¹; Sung, Jean C²; Edwards, David A³

Source: Expert Opinion on Drug Delivery, Volume 4, Number 6, November 2007 , pp. 651-663(13)

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Abstract:

The development of needle-less vaccination for pulmonary delivery may require dry forms of vaccines whose powder properties allow for a low cost, heat and freeze tolerance, efficient aerosolization, and the ability to target cells of the immune system. For each of these reasons, nanoparticles can play a critical role in the formulation, development and delivery of needle-less vaccination. This review aims to communicate present biomaterial design issues surrounding the incorporation of nanoparticles into pulmonary vaccines.

Keywords: adjuvants; aerosols; biocompatible polymers; microparticles; nanoparticles; poly(lactic-co-glycolic acid); pulmonary delivery; vaccines

Document Type: Research article

DOI: http://dx.doi.org/10.1517/17425247.4.6.651

Affiliations: 1: 1Graduate Program in Biophysics, Harvard University Faculty of Arts and Sciences, 40 Oxford Street, ESL 406, Cambridge, MA 02138, USA 2: 2Graduate Program in Bioengineering, Harvard School of Engineering and Applied Sciences, 40 Oxford Street, ESL 406, Cambridge, MA 02138, USA 3: 3Gordon McKay Professor of the Practice of Biomedical Engineering, Harvard School of Engineering and Applied Sciences, 322 Pierce Hall, 29 Oxford Street, Cambridge, MA 02138, USA +1 617 495 1328; +1 617 495 9837;, Email: dedwards@seas.harvard.edu

Publication date: 2007-11-01

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