Electroporation-mediated gene therapy

Authors: Isaka, Yoshitaka¹; Imai, Enyu²

Source: Expert Opinion on Drug Delivery, Volume 4, Number 5, September 2007 , pp. 561-571(11)

Buy & download fulltext article:

Price: $99.00 plus tax (Refund Policy)

Abstract:

Non-viral gene transfer is markedly enhanced by the application of in vivo electroporation. Electroporation is a safe and efficient system to introduce genes to a wide variety of tissues, including skeletal muscle, tumors, kidney, liver and skin. Electroporation has been demonstrated to be effective in numerous disease models. This review focuses on the principles of electroporation and the target tissues employed for gene therapy. Based on the accumulation of positive results, the first clinical study for the treatment of malignant melanoma is now underway, and preclinical studies have suggested that electroporation is useful as a gene therapy protocol.

Keywords: cytokine; DNA vaccine; electroporation; erythropoietin; IL-12

Document Type: Research article

DOI: http://dx.doi.org/10.1517/17425247.4.5.561

Affiliations: 1: 1Associate Professor, Osaka University Graduate School of Medicine, Divisions of Advanced Technology for Transplantation and Nephrology, Suita, Osaka 565-0871, Japan +81 6 6879 3746; +81 6 6879 3749;, Email: isaka@att.med.osaka-u.ac.jp 2: 2Associate Professor, Osaka University Graduate School of Medicine, Division of Nephrology, Suita, Osaka 565-0871, Japan

Publication date: 2007-09-01

More about this publication?