Authors: Weers, Jeffry G¹; Tarara, Thomas E²; Clark, Andrew R³

Source: Expert Opinion on Drug Delivery, Volume 4, Number 3, May 2007 , pp. 297-313(17)

Publisher: Informa Healthcare

Abstract:

Particle design for inhalation is characterized by advances in particle processing methods and the utilization of new excipients. Processing methods such as spray drying allow control over critical particle design features, such as particle size and distribution, surface energy, surface rugosity, particle density, surface area, porosity and microviscosity. Control of these features has enabled new classes of therapeutics to be delivered by inhalation. These include therapeutics that have a narrow therapeutic index, require a high delivered dose, and/or elicit their action systemically. Engineered particles are also being utilized for immune modulation, with exciting advances being made in the delivery of antibodies and inhaled vaccines. Continued advances are expected to result in `smart' therapeutics capable of active targeting and intracellular trafficking.

Keywords: absorption enhancer; aerosol; amorphous glass; anti-infective; dry powder inhaler; immunoglobulin; inhalation; particle engineering; peptide; porous particle; powder formulation; protein; pulmonary drug delivery; spray drying; spray freeze drying; supercritical fluid; systemic drug administration; vaccine

Document Type: Research article

DOI: http://dx.doi.org/10.1517/17425247.4.3.297

Affiliations: 1: 1Senior Fellow, Nektar Therapeutics, 150 Industrial Road, San Carlos, CA 94070, USA., Email: jweers@ca.nektar.com 2: 2Senior Staff Scientist, Nektar Therapeutics, 150 Industrial Road, San Carlos, CA 94070, USA 3: 3Chief Technical Officer, Nektar Therapeutics, 150 Industrial Road, San Carlos, CA 94070, USA

Publication date: 2007-05-01

More about this publication?

• Editorial Board
• Information for Authors
• Subscribe to this Title
• Terms & Conditions
• ingentaconnect is not responsible for the content or availability of external websites

Related content

• In this: publication
• By this: publisher
• In this Subject: Pharmacology
• By this author: Weers, Jeffry G ;  Tarara, Thomas E ;  Clark, Andrew R

Website © Publishing Technology. Article copyright remains with the publisher, society or author(s) as specified within the article.

• Terms and conditions
• Privacy policy
• Information for advertisers