Home >> Expert Opinion on Drug Delivery, Volume 4, Number 3

Drug delivery via nano-, micro and macroporous coronary stent surfaces

Authors: Tsujino, Ichizo1; Ako, Junya2; Honda, Yasuhiro3; Fitzgerald, Peter J4

Source: Expert Opinion on Drug Delivery, Volume 4, Number 3, May 2007 , pp. 287-295(9)

Publisher: Informa Healthcare

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Abstract:

Drug-eluting stents (DESs) have revolutionized the treatment of occlusive coronary artery disease via marked reduction of in-stent restenosis. One critical feature for successful DESs is the sustained release of drugs, which is achieved using a polymer coating in the present generation of DESs. However, recent studies have raised a concern that polymers may trigger allergic reactions and/or prolonged inflammation in some patients. These untoward reactions may eventually lead to undesirable clinical events, including stent thrombosis and sudden cardiac death. A new drug delivery technology, using a porous stent surface, may offer desirable drug elution properties without the use of polymers, and may translate into an improved safety profile for the next-generation DESs.

Keywords: coronary intervention; coronary stent; porous surface; restenosis

Document Type: Research article

DOI: http://dx.doi.org/10.1517/17425247.4.3.287

Affiliations: 1: 1Senior Research fellow, Stanford University Medical Center, Division of Cardiovascular Medicine, Stanford, CA, USA 2: 2Director of Academic affairs, Stanford University Medical Center, Division of Cardiovascular Medicine, Stanford, CA, USA 3: 3Co-director of Center for Research in Cardiovascular Interventions, Stanford University Medical Center, Division of Cardiovascular Medicine, Stanford, CA, USA 4: 4Professor of Medicine (Cardiology) and Engineering (Courtesy) and Director, Center for Cardiovascular Technology, Stanford University Medical Center, 300 Pasteur Drive, Room H3554, Stanford, CA 94305, USA., Email: crci-cvmed@stanford.edu

Publication date: 2007-05-01

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