Emollient foam in topical drug delivery

Authors: Tamarkin, Dov¹; Friedman, Doron²; Shemer, Avner³

Source: Expert Opinion on Drug Delivery, Volume 3, Number 6, November 2006 , pp. 799-807(9)

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Abstract:

Foams offer an innovative and more convenient means of topical drug delivery. The successful introduction of hydroalcoholic foams paved the way for the development of a new generation of foam products that provide skin barrier build-up and hydration. Such foams, designated as emollient foams consist of oil-in-water or water-in-oil emulsions with necessary excipients, such as non-ionic surfactants, gelling agents and foam adjuvants. Emollient foams can carry a broad variety of topical drugs, including water-soluble, oil-soluble and suspended active agents. This paper reviews emollient foam compositions and their physicochemical properties. It further accounts for the usability and functional advantages of emollient foam as a vehicle of topical drugs, including: i) improved usability, which affects treatment, compliance and, consequently, improves therapeutic results; ii) safety; iii) controllable drug delivery; iv) skin barrier build-up and hydration; and v) enhanced clinical efficacy.

Keywords: emollient foam; skin penetration; topical therapy; usability

Document Type: Research article

DOI: http://dx.doi.org/10.1517/17425247.3.6.799

Affiliations: 1: 1Chief Executive Officer, Foamix Ltd, 2 Holzman Street, Weizmann Science Park, PO Box 4038, Ness Ziona 74140, Israel 2: 2Chief Technical Officer, Foamix Ltd, Weizmann Science Park, 2 Holzman Street, PO Box 4038, Ness Ziona 74140, Israel 3: 3Dermatologist, Clinical Investigator, Laniado-Sanz Medical Center, Netanya, Israel.

Publication date: 2006-11-01

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