Non-invasive routes for insulin administration: current state and perspectives
Source: Expert Opinion on Drug Delivery, Volume 3, Number 6, November 2006 , pp. 763-770(8)
Publisher: Informa Healthcare
Abstract:Diabetes mellitus is a chronic disease that usually requires multiple insulin injections to achieve adequate glycaemic control. This represents a major cause of reduced compliance to treatment. Consequently, other routes for insulin administration have been explored. During recent years, much progress in the development of inhaled insulin has been made. Inhaled insulin has shown favourable properties, such as a rapid onset of action, improved bioavailability and good tolerability; thereby providing satisfaction and ease of administration. However, long-term safety of inhaled insulin needs to be assessed, and the cost would be higher than injectable insulin. Nasal, oral and transdermal insulins are undergoing early phases of pharmacological development. The purpose of this review is to describe the latest developments in the area of non-invasive routes for insulin delivery.
Document Type: Research Article
Affiliations: 1: 1Professor and Head, Department of Pharmacology, Instituto Universitario, CEMIC, Galvan 4102, Ciudad Autónoma de Buenos Aires, Argentina 2: 2Clinical Research Associate of Medical Department, Medical Department, Novo Nordisk Pharma Argentina, Avenida del Libertador 14099, Martinez, CP:B1640AOL, Provincia de Buenos Aires, Argentina 3: 3Professor of Internal Medicine, Department of Internal Medicine, School of Medicine, Universidad de la Plata, Calle 9N175 CP 1900, La Plata, Provincia de Buenos Aires, Argentina 4: 4Professor and Head of Pharmacology, Department of Physiological , Biochemistry and Pharmacological Sciences, School of Medicine, Universidad Favaloro, Solis 453, CP 1078, Ciudad Autónoma de Buenos Aires, Argentina 5: 6Lecturer in Pharmacology, Department of Pharmacology, School of Medicine, Universidad de Buenos Aires, Paraguay 2215, Piso 16, CP:C1121ABG, Ciudad Autónoma de Buenos Aires, Argentina
Publication date: November 1, 2006