New advances in aerosolised drug delivery: vibrating membrane nebuliser technology

Authors: Lass, Joseph S¹; Sant, Andrew²; Knoch, Martin³

Source: Expert Opinion on Drug Delivery, Volume 3, Number 5, September 2006 , pp. 693-702(10)

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Abstract:

Innovative nebuliser systems bear the potential to greatly improve and expand the administration of therapeutic aerosols for the treatment of respiratory diseases. Exploiting the technology of a microperforated vibrating membrane offers a close control of the droplet size that is being generated and targeted to reach the lower airways, with little oropharyngeal deposition, thereby reducing undesired side effects. The greatly improved efficiency of such devices, as exemplified by the eFlow^® nebuliser (PARI), provides further advantages for the patient. A high respirable fraction due to the precisely defined perforations, low residual losses and the high liquid output rate combine to produce a highly efficient and fast administration of inhaled medications. Portability, ease of handling and noiseless operation have a positive effect on patient compliance, control of the therapy by the physician and the therapy costs.

Keywords: aerosol; droplet size targeting; microperforated membrane; nebulisation time; nozzle; respirable dose; vibrating membrane nebuliser

Document Type: Research article

DOI: http://dx.doi.org/10.1517/17425247.3.5.693

Affiliations: 1: 1PARI GmbH, Aerosol Research Institute, Steinerstrasse 15 K, 81369 Munich, Germany., Email: j_lass@pari.de 2: 2The Technology Partnership plc, Melbourn Science Park, Melbourn, Hertfordshire, SG8 6EE, UK 3: 3PARI GmbH, Aerosol Research Institute, Steinerstrasse 15 K, 81369 Munich, Germany

Publication date: 2006-09-01

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