Author: Lewis, Andrew L

Source: Expert Opinion on Drug Delivery, Volume 3, Number 2, 1 March 2006 , pp. 289-298(10)

Publisher: Informa Healthcare

Abstract:

Hydrogel polymers incorporating phosphorylcholine have found widespread use in the manufacture of medical devices with improved haemo- and biocompatibility. Examples include soft contact lenses or coatings for devices, such as coronary stents and extracorporeal circuits. The advent of drug-device combinations has prompted the application of PC Technology™ (Biocompatibles UK Ltd) as a bioinert drug delivery vehicle, particularly in the form of coatings, for targeted delivery from a device surface. The flexible polymer chemistry employed in the synthesis of these materials offers a range of molecular architectures that could find applicability in a wide variety of drug delivery applications, including micellar, vesicular and gel systems, and even drug conjugation.

Keywords: biocompatibility; combination product; gene therapy; hydrogels; medical device; micelles; PCylation; phosphorylcholine; stimulus-responsive materials; targeted drug delivery

Document Type: Miscellaneous

DOI: http://dx.doi.org/10.1517/17425247.3.2.289

Publication date: 2006-03-01

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