Closed-loop insulin delivery – what lies between where we are and where we are going?
Authors: Steil, Garry M; Rebrin, Kerstin
Source: Expert Opinion on Drug Delivery, Volume 2, Number 2, 1 March 2005 , pp. 353-362(10)
Publisher: Informa Healthcare
Abstract:Closed-loop insulin delivery in individuals with diabetes can potentially lead to near-normal glucose profiles. To this end, existing subcutaneous glucose sensors and external insulin pumps can be linked with an insulin delivery algorithm to create a completely automated closed-loop system. This paper reviews current research into the development of such a system, with particular emphasis on creating a system emulating the physiological properties of the -cell. Issues related to using subcutaneous interstitial fluid for glucose -sensing and insulin delivery are reviewed. Criteria for optimising the system are discussed using historical data. Existing strategies for open-loop pump therapy are presented with the objective of defining a path to advance from the existing physician/patient determined insulin therapy to a completely automated system.
Document Type: Review Article
Publication date: March 1, 2005