TARGIT™ technology: coated starch capsules for site-specific drug delivery into the lower gastrointestinal tract

Authors: Watts, Peter; Smith, Alan

Source: Expert Opinion on Drug Delivery, Volume 2, Number 1, 1 January 2005 , pp. 159-167(9)

Publisher: Informa Healthcare

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Abstract:

TARGIT™ technology (West Pharmaceutical Services) is designed for site-specific delivery of drugs in the gastrointestinal (GI) tract and, in particular, targeted release into the colonic region. A key area of application is the delivery of therapeutic agents for local treatment of lower GI diseases. The technology is based on the application of pH-sensitive coatings onto injection-moulded starch capsules. An extensive body of clinical data has been generated showing reliable invivo performance of the capsules. In -scintigraphy studies around 90% of TARGIT capsules (n = 84) delivered their contents to the target site of the terminal ileum and colon. TARGIT-based products are in active clinical development for the treatment of conditions including inflammatory bowel diseases.

Keywords: colon; pH-sensitive coating; site-specific; starch capsule

Document Type: Miscellaneous

DOI: http://dx.doi.org/10.1517/17425247.2.1.159

Publication date: January 1, 2005

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