Tumour-selective drug delivery via folate receptor-targeted liposomes

Authors: Xiaogang Pan; Robert J Lee

Source: Expert Opinion on Drug Delivery, Volume 1, Number 1, 1 November 2004 , pp. 7-17(11)

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Abstract:

Tumour cell-targeted liposomal delivery has the potential to enhance the therapeutic efficacy and reduce the toxicity of anticancer agents. Folate receptor (FR) expression is frequently amplified among human malignancies. FR is, therefore, potentially useful as a tumour marker for targeted drug delivery. FR-mediated liposomal delivery has been shown to enhance the antitumour efficacy of doxorubicin both in vitro and in vivo, and to overcome P-glycoprotein-mediated multi-drug resistance. In addition, FR-targeted liposomes have shown utility as effective delivery vehicles of genes and antisense oligodeoxyribonucleotides to FR(+) tumour cells. Both solid tumours and leukaemias can potentially benefit from FR-targeted drug delivery. Multiple mechanisms might contribute to greater therapeutic efficacy for FR-targeted liposomes, such as FR-dependent cytotoxicity and antiangiogenic activity. Further investigation of this promising drug delivery strategy is clearly warranted.

Keywords: angiogenesis; antisense oligodeoxyribonucleotides; chemotherapy; folate receptor; gene therapy; liposome; multi-drug resistance; targeted drug delivery

Document Type: Review article

DOI: http://dx.doi.org/10.1517/17425247.1.1.7

Publication date: 2004-11-01

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