Natural killer: can they be useful as adoptive immunotherapy for cancer?

Authors: Sally Arai; Hans-G Klingemann

Source: Expert Opinion on Biological Therapy, Volume 5, Number 2, 1 February 2005 , pp. 163-172(10)

Publisher: Informa Healthcare

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Abstract:

As part of the innate immune system, natural killer (NK) cells form the first line of defence against pathogens or transformed/cancerous host cells. Recent experimental and clinical data show the possibility of exploiting NKactivity as a cell-based immunotherapy to treat cancer. This review di-scusses the recent knowledge on NK cell biology that has impacted on its development as a treatment for cancer.

Keywords: cancer; immunotherapy; natural killer cells

Document Type: Review article

DOI: 10.1517/14712598.5.2.163

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