IngentaConnect Effect of gliclazide modified release on adiponectin, interleukin...

Abstract:

Objective: The aim of the study was to evaluate the effect of gliclazide modified release (MR) treatment on adiponectin, interleukin 6 (IL-6), and tumor necrosis factor-α (TNF-α) plasma concentrations in type 2 diabetic patients.

Research design and methods: 24 randomly selected type 2 diabetic patients, aged 61.2 ± 15.4 years, with poorly controlled glucose level (mean glycated hemoglobin [HbA_1c] 7.6 ± 1.1%) despite treatment with diet and/or oral hypoglycemic agents, were included in the study. All of the patients, after a 2-week run-in period, were given gliclazide MR for 12 weeks. At baseline, and after gliclazide MR treatment, HbA_1c and plasma concentrations of IL-6, TNF-α, and adiponectin were measured.

Results: Gliclazide MR treatment produced significant reductions in fasting plasma glucose (from 7.6 ± 1.4 to 6.6 ± 1.2 mmol/L, p < 0.01), HbA_1c (from 7.6 ± 1.1 to 6.9 ± 0.8%, p < 0.01), and plasma IL-6 concentrations (from 2.5 ± 1.8 to 1.8 ± 1.2 pg/mL, p < 0.05). A significant increase in plasma adiponectin level was noted (from 6.4 ± 3.3 to 7.6 ± 4.4 μg/mL, p < 0.05). Plasma TNF-α concentrations and homeostasis model assessment of insulin resistance (HOMA-IR) decreased after treatment, but these changes did not reach statistical significance.

Conclusions: Gliclazide MR improves glycemic control and, in addition, has a positive influence on the plasma level of some inflammatory markers and adiponectin. Increased plasma adiponectin and decreased plasma IL-6, and TNF-α levels may explain, at least in part, the anti-atherogenic action of this drug reported elsewhere.

Keywords: ADIPONECTIN; GLICLAZIDE MODIFIED RELEASE; INTERLEUKIN-6; TUMOR NECROSIS FACTOR-ALPHA

Document Type: Short communication

DOI: 10.1185/030079906X132424

Affiliations: 1: Department of Internal Medicine, Diabetology and Clinical Pharmacology, Medical University of Łódź, Poland

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Effect of gliclazide modified release on adiponectin, interleukin-6, and tumor necrosis factor-α plasma levels in individuals with type 2 diabetes mellitus