IngentaConnect Alcoholic hepatitis: from pathogenesis to treatment

Authors: Sougioultzis, S.¹; Dalakas, E.¹; Hayes, P.C.¹; Plevris, J.N.¹

Source: Current Medical Research and Opinion, Volume 21, Number 9, September 2005 , pp. 1337-1346(10)

Abstract:

Alcoholic hepatitis is a serious complication of alcohol abuse due to its high mortality rates particularly at short term. It may complicate pre-existing alcoholic fatty liver or cirrhosis and is mainly diagnosed on clinical and laboratory grounds although liver biopsy is occasionally needed to exclude other pathology and confirm the diagnosis. Accumulating evidence suggests that cytokines and immunity are actively involved in its pathogenesis. Management includes abstinence and supportive care. Treatment with corticosteroids has been studied in several clinical trials with conflicting results. However, recent evidence supporting the beneficial effect of TNF-α inhibition provides an encouraging alternative. Here we summarise the current state in diagnosis and management of alcoholic hepatitis and briefly review the latest advances in pathophysiology that may lead to new therapeutic strategies for this difficult clinical condition. Data sources: Medline 1966–2005, EMBASE/Excerpta Medica 1980–2005, The Cochrane Library (2005 Issue 2) and contact with authors of published reports.

Keywords: ALCOHOLIC HEPATITIS; DIAGNOSIS; MANAGEMENT; PATHOPHYSIOLOGY; TNF-ALPHA INHIBITION

Document Type: Review article

DOI: 10.1185/030079905X56493

Affiliations: 1: Department of Hepatology, The Royal Infirmary of Edinburgh and University of Edinburgh, UK

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