Update on PET glucose neuroimaging

Authors: Buchsbaum M. S.; Hazlett E. A.

Source: International Review of Psychiatry, Volume 9, Number 4, 1 December 1997 , pp. 339-354(16)

Publisher: Informa Healthcare

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Abstract:

Summary Positron emission tomography with 18F-deoxyglucose yields high-resolution images of brain activity with accurate quantification of a fundamental property of central nervous system function, cerebral glucose metabolic rate. Alone among brain-imaging modalities, the deoxyglucose method can be applied with microscopic resolution in animal studies, permitting detailed comparison of pharmacological response in both human and non-human experiments. In schizophrenia, metabolic imaging has identified functional changes in components of the fronto-striato-thalamic circuits and the temporal lobe, and visualized changes with neuroleptic, anxiolytic and antidepressant treatment.

Language: English

Document Type: Research article

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