Author: Kato, Jun-ichi

Source: Critical Reviews in Biochemistry and Molecular Biology, Volume 40, Number 6, Number 6/November-December 2005 , pp. 331-342(12)

Publisher: Informa Healthcare

Abstract:

The bacterial chromosome is replicated once during the division cycle, a process ensured by the tight regulation of initiation at oriC . In prokaryotes, the initiator protein DnaA plays an essential role at the initiation step, and feedback control is critical in regulating initiation. Three systems have been identified that exert feedback control in Escherichia coli , all of which are necessary for tight strict regulation of the initiation step. In particular, the ATP-dependent control of DnaA activity is essential. A missing link in initiator activity regulation has been identified, facilitating analysis of the reaction mechanism. Furthermore, key components of this regulatory network have also been described. Because the eukaryotic initiator complex, ORC, is also regulated by ATP, the bacterial system provides an important model for understanding initiation in eukaryotes. This review summarizes recent studies on the regulation of initiator activity.

Keywords: DnaA; oriC; Hda; sliding clamp

Document Type: Research article

DOI: http://dx.doi.org/10.1080/10409230500366090

Affiliations: 1: Department of Biology, Graduate School of Science, Tokyo Metropolitan University, Minamiohsawa, Hachioji, Tokyo, Japan

Publication date: 2005-11-01

More about this publication?

• Information for Authors
• Subscribe to this Title
• Terms & Conditions
• ingentaconnect is not responsible for the content or availability of external websites

Related content

• In this: publication
• By this: publisher
• By this author: Kato, Jun-ichi

Website © Publishing Technology. Article copyright remains with the publisher, society or author(s) as specified within the article.

• Terms and conditions
• Privacy policy
• Information for advertisers