RNA-Binding Proteins in Early Development

Authors: Colegrove-Otero, Lucy; Minshall, Nicola; Standart, Nancy

Source: Critical Reviews in Biochemistry and Molecular Biology, Volume 40, Number 1, January-February 2005 , pp. 21-73(53)

Publisher: Informa Healthcare

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Abstract:

RNA-binding proteins play a major part in the control of gene expression during early development. At this stage, the majority of regulation occurs at the levels of translation and RNA localization. These processes are, in general, mediated by RNA-binding proteins interacting with specific sequence motifs in the 3'-untranslated regions of their target RNAs. Although initial work concentrated on the analysis of these sequences and their trans -acting factors, we are now beginning to gain an understanding of the mechanisms by which some of these proteins function. In this review, we will describe a number of different families of RNA-binding proteins, grouping them together on the basis of common regulatory strategies, and emphasizing the recurrent themes that occur, both across different species and as a response to different biological problems.

Keywords: C. elegans; Drosophila; oocyte; RNA localization; translational control; Xenopus

Document Type: Research article

DOI: http://dx.doi.org/10.1080/10409230590918612

Affiliations: 1: Department of Biochemistry, University of Cambridge, Cambridge, England

Publication date: 2005-01-01

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