Authors: Danielsson R.¹; Reihnér E.²; Grabowska A.²; Boné B.¹

Source: Acta Radiologica, Volume 41, Number 5, 1 September 2000 , pp. 441-445(5)

Publisher: Informa Healthcare

Abstract:

Purpose:

To prospectively determine the clinical value of scintimammography (Sc) with ^99mTc-sestamibi as a complementary method to triple diagnosis (TD) in detecting malignant disease of the breast.

Material and Methods:

Ninety-six patients with 119 clinically or mammographically detected breast lesions underwent TD procedures, including clinical examination, mammography and fine-needle aspiration cytology. Prone planar Sc with ^99mTc-sestamibi was performed in all 96 patients. Five groups were defined for diagnosis: 1=normal; 2=benign; 3=probably benign; 4=highly suspect of malignancy; and 5=malignant. All lesions were histopathologically examined. The results of each method per se and the combination of TD with Sc (TD+Sc) were analyzed.

Results:

Histopathology of the 119 surgically excised breast lesions found 83 malignant and 36 benign lesions. TD missed 6 of 83 carcinomas, resulting in a sensitivity of 92.7%. Sc alone showed sensitivity of 85.5%. The combination TD+Sc missed 1 of 83 carcinomas, and thus had a sensitivity of 98.7%. In mammographically dense breasts both TD and Sc detected 16 of 18 carcinomas, while the combination TD+Sc led to detection of all 18 carcinomas.

Conclusion:

Adding Sc to TD increases the sensitivity for detection of breast carcinomas. Sc with ^99mTc-sestamibi is recommended as a complimentary method to TD in selected cases such as mammographically dense breasts.

Keywords: Breast carcinoma, triple diagnosis; scintimammography; diagnostic accuracy

Document Type: Original article

DOI: http://dx.doi.org/10.1080/028418500127345659

Affiliations: 1: Departments of Diagnostic Radiology and 2: Surgery, Karolinska Institutet, Huddinge University Hospital, Huddinge, Sweden.

Publication date: 2000-09-01

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