Premalignant epithelial disorders of the vulva: squamous vulvar intraepithelial neoplasia, vulvar Paget's disease and melanoma in situ
Source: Acta Obstetricia et Gynecologica Scandinavica, Volume 89, Number 6, June 2010 , pp. 741-748(8)
Publisher: Informa Healthcare
No standard screening programs exist to detect vulvar carcinoma or its precursor lesions, and therefore gynecologists, dermatologists and other healthcare providers in this field should be aware of the clinical features, behavior and management of the different existing premalignant vulvar lesions, squamous vulvar intraepithelial neoplasia (VIN), vulvar Paget's disease and melanoma in situ. In 2004, a new classification for squamous VIN was introduced by the International Society for the Study of Vulvar Disease, subdividing squamous VIN into the HPV-related usual type, and into differentiated type, which is associated with lichen sclerosus. This review describes the relevant aspects of squamous VIN, vulvar Paget's disease and melanoma in situ, its epidemiological characteristics, diagnosis, management and malignant potential.
Document Type: Research Article
Affiliations: 1: 1Departments of Obstetrics and Gynecology, Erasmus University Medical Center, Rotterdam, The Netherlands 2: 2Department of Gynecology, The Netherlands Cancer Institute, Amsterdam, The Netherlands
Publication date: June 1, 2010