Maternal use of thyroid hormones in pregnancy and neonatal outcome

Authors: Norstedt Wikner, Birgitta1; Skjoldebrand Sparre, Lottie2; Stiller, Carl-Olav1; Kallen, Bengt3; Asker, Charlotte1

Source: Acta Obstetricia et Gynecologica Scandinavica, Volume 87, Number 6, 2008 , pp. 617-627(11)

Publisher: Informa Healthcare

Buy & download fulltext article:

The full text article is not available for purchase.

The publisher only permits individual articles to be downloaded by subscribers.

Abstract:

Objective. To describe neonatal outcome including the presence of congenital malformations in infants born to women substituted with thyroid hormones, and the maternal characteristics of these women. Design. Register study based on prospectively collected data in relation to delivery. Setting. Swedish Health Registers. Population. All pregnant women (n=848,468) and all infants born (n=861,989) in Sweden from 1 July 1995 to 31 December 2004. Methods. Women who reported the use of thyroid hormones in early pregnancy or obtained a prescription for thyroid hormones later in pregnancy (n=9,866), as well as their infants (n=10,055) were identified from the Swedish Medical Birth Register. The reference population consisted of all women giving birth and their offspring during the same time interval. Main outcome measures. Neonatal outcome, malformations and maternal characteristics. Data were analyzed with adjustments for identified confounders. Results. Women using thyroxine had an increased rate of pre-eclampsia, diabetes (pre-existing or gestational), cesarean sections and inductions of labour compared to women in the reference population. The risk for preterm birth was marginally increased (OR 1.13, 95% CI 1.03-1.25). Neonatal thyroid disease was found in eight infants (seven with thyreotoxicosis and one unspecified), the expected number was 0.2. No further anomalies in neonatal diagnoses were found. A small but statistically significant risk for congenital malformations (OR =1.14, 95% CI 1.05-1.26) was found. Conclusion. Women on thyroid substitution during pregnancy had an increased risk for some pregnancy complications, but their infants were only slightly affected.

Keywords: Thyroid hormone substitution; malformations; maternal outcome; neonatal outcome

Document Type: Research Article

DOI: http://dx.doi.org/10.1080/00016340802075103

Affiliations: 1: Department of Medicine, Karolinska Institutet, Clinical Pharmacology Unit, Karolinska University Hospital, Stockholm, Solna, Sweden 2: Division of Obstetrics and Gynecology, Karolinska Institutet, Danderyd Hospital, Stockholm, Sweden 3: Tornblad Institute, University of Lund, Lund, Sweden

Publication date: January 1, 2008

More about this publication?

Key

Free Content
Free content
New Content
New content
Open Access Content
Open access content
Subscribed Content
Subscribed content
Free Trial Content
Free trial content

Text size:

A | A | A | A
Share this item with others: These icons link to social bookmarking sites where readers can share and discover new web pages. print icon Print this page