Authors: Kelekci, Sefa¹; Erdemoglu, Evrim²; İnan, İsmet¹

Source: Acta Obstetricia et Gynecologica Scandinavica, Volume 85, Number 7, June 2006 , pp. 825-829(5)

Publisher: Informa Healthcare

Abstract:

Objective. To compare effectiveness of misoprostol and ethacridine lactate with or without oxytocin in second-trimester medical abortions. Subjects and methods. A randomized prospective study. A total of 388 women with genetic indications for termination of pregnancy at 13-24 weeks of gestation were recruited. Group I ( n =85) were treated with extra-amniotic ethacridine lactate, 10ml instilled per gestational week, to a maximum of 200ml. Group II ( n =93) were treated with misoprostol administered intravaginally (200 µ g), followed by 100 µ g of oral misoprostol 4 hourly for 24h. Group III ( n =102) were treated with a combination of ethacrine lactate and oxytocin. An initial dose of 6mU/min oxytocin was given, followed by additional 6mU/min doses every 20 min. Group IV ( n =96) were treated with a combination of misoprostol and oxytocin administered in a similar way as in group III. The main outcome measures were time to induce abortion, side effects, and failure/success rates. Results. The mean time to induce abortion was 14.2±3.6, 13.2±3.4, 10.8±2.6, and 9.9±2.4 h in groups I, II, III, and IV, respectively ( p <0.001). Addition of oxytocin to ethacridine lactate did not decrease the risk of prolongation of induction beyond 24 h but use of oxytocin with misoprostol did reduce the risk of induction beyond 24 h (OR: 0.46, 95%CI: 0.21-1, p <0.05). The occurrence of minor side effects was similar in all groups. Conclusion. Addition of oxytocin to ethacridine lactate or misoprostol significantly decreases the length of time to induce abortion without supplementary side effects.

Keywords: ethacridine lactate; misoprostol; oxytocin; second-trimester abortion

Document Type: Research article

DOI: http://dx.doi.org/10.1080/00016340500345337

Affiliations: 1: Department of Obstetrics and Gynecology, Ankara Education and Research Hospital, Ankara, Turkey 2: Department of Obstetrics and Gynecology, TSK Ankara Mevki Soldier Hospital, Ankara, Turkey

Publication date: 2006-06-01

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