Interaction with Human Immunodeficiency Virus (HIV) Type 2 Predicts HIV Type 1 Genotype

Authors: Sarr A.D.¹; Sankalé J-L.¹; Hamel D.J.¹; Travers K.U.¹; Guèye-Ndiaye A.²; Essex M.¹; Mboup S.²; Kanki P.J.¹

Source: Virology, Volume 268, Number 2, March 2000 , pp. 402-410(9)

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Abstract:

In West Africa, India, and certain regions of Europe, both human immunodeficiency viruses types 1 and 2 (HIV-1 and HIV-2) are known to cocirculate. To investigate the HIV-1 subtypes involved in dual HIV-1 and HIV-2 infections, we sequenced the envelope C2–V3 region from 29 dually infected female commercial sex workers from Senegal. The majority of women (23 of 29) were infected by HIV-1 subtype A. Within the HIV-1 subtype A sequences, 14 of 23 (60.8%) clustered with the West African associated A/G recombinant form (IbNG), and 9 of 23 (39.2%) formed a separate cluster distinct from the A/G IbNG. In contrast, in HIV-1 singly infected individuals, non-IbNG subtype A was found in only 13 of 98 (13.3%). Therefore, the lack of protection and/or interaction with HIV-2 was associated with a distinct HIV-1 A genotype. These results suggest differences in the biological properties of HIV-1 genotypes and their in vivo interaction with HIV-2. Copyright 2000 Academic Press.

Language: English

Document Type: Research article

Affiliations: 1: Department of Immunology and Infectious Diseases and the Harvard AIDS Institute, Harvard School of Public Health, 651 Huntington Avenue, Boston, Massachusetts, 02115 2: Laboratoire de Bactériologie-Virologie, Université Cheikh Anta Diop, Dakar, Senegal

Publication date: 2000-03-01