Molecular Epidemiology of HTLV-II among United States Blood Donors and Intravenous Drug Users: An Age-Cohort Effect for HTLV-II RFLP Type a0

Authors: Murphy E.L.¹; Mahieux R.²; de The G.²; Tekaia F.³; Ameti D.⁴; Horton J.⁴; Gessain A.²

Source: Virology, Volume 242, Number 2, March 1998 , pp. 425-434(10)

Publisher: Academic Press

Abstract:

Molecular subtyping was used to investigate the epidemiology of human T-lymphotropic virus type II (HTLV-II) in the United States. Nested polymerase chain reaction of the HTLV-II long terminal repeat region followed by restriction fragment length polymorphism (RFLP) analysis was performed on HTLV-II seropositive subjects including 97 U.S. blood donors without major risk factors for HTLV-II infection, 53 injection drug users (IDU), and 10 American Indian blood donors. Three new HTLV-II RFLP types were confirmed with DNA sequencing and phylogenetic analysis. HTLV-II RFLP type a0 (Switzer classification) was associated with older age [adjusted odds ratio (OR) 1.06 per year of age, 95% confidence interval (CI) 1.02-1.09] and with Black (OR 5.24, 95% CI 1.90-14.47) and White (OR 4.43, 95% CI 1.67-11.75) race/ ethnicity. These data are consistent with an age-cohort effect for HTLV-II RFLP type a0 among older White and Black IDU and blood donors. This finding could be explained by an epidemic of non-a0 HTLV-II RFLP types among younger persons of Hispanic and other race/ethnicity, superimposed upon endemic HTLV-II RFLP type a0 among older Black and White persons. Copyright 1998 Academic Press.

Language: English

Document Type: Research article

Affiliations: 1: Departments of Laboratory Medicine, Medicine and Epidemiology/Biostatistics, University of California San Francisco, San Francisco, California, 94143 2: Unite d'Epidemiologie des Virus Oncogenes 3: Unite d'Epidemiologie des Virus Oncogenes, Unite de Genetique Moleculaire des Levures, Institut Pasteur, Paris, France 4: Westat Inc., Rockville, Maryland

Publication date: 1998-03-01

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