Calcium dependence of neurotransmitter release

Authors: Matthews G.; von Gersdorff H.

Source: Seminars in Neuroscience, Volume 8, Number 5, October 1996 , pp. 329-334(6)

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Abstract:

Neurotransmitter is released from synaptic terminals by rapid and highly targeted fusion of synaptic vesicles with the presynaptic membrane. Several lines of evidence suggest that the trigger for vesicle fusion is the large increase in internal [Ca ] (up to hundreds of micromolar) achieved within the submicroscopic domain of elevated calcium near open calcium channels. The rapid rise and fall of [Ca ] in this microdomain, together with the fast kinetics of the calcium-triggered fusion machinery, account for the speed of synaptic exocytosis.

Keywords: exocytosis

Language: English

Document Type: Miscellaneous

Affiliations: From the Department of Neurobiology and Behavior, State University of New York, Stony Brook, NY, 11794-5230, USA

Publication date: 1996-10-01