Early phenotypic changes of in vitro transformed cells during in vivo progression: possible role of the host innate immunity

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By this: publisher
In this Subject: Biology ,&nbsp; Oncology
By this author: Deichman G.I.

Author: Deichman G.I.

Source: Seminars in Cancer Biology, Volume 12, Number 4, August 2002 , pp. 317-326(10)

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Abstract:

We described the earliest in vivo changes ofin vitro transformed cells of various origin manifested in highly-increased H₂O₂-catabolizing and PGE₂-releasing activities. We designate it as [\mathrm{{H}}_{\scriptscriptstyle{{\mathrm{2}}}}\mathrm{{O}}_{\scriptscriptstyle{\mathrm{2}}}^{\scriptscriptstyle{\mathrm{{CA}}}}+\mathrm{{PGE^{\scriptscriptstyle{{S}}}}}]-phenotype. It provided tumor cells with resistance to cytotoxicity of Mph and NK cells and correlated with increased tumorigenicity. Used as a functional marker of the early step of in vivo tumor progression [\mathrm{{H}}_{\scriptscriptstyle{{\mathrm{2}}}}\mathrm{{O}}_{\scriptscriptstyle{\mathrm{2}}}^{\scriptscriptstyle{\mathrm{{CA}}}}+\mathrm{{PGE^{\scriptscriptstyle{{S}}}}}]-phenotype allowed to estimate the difference in the rates of natural selection of tumor cells grown locally and/or disseminated and its significant delay related tobcl-2 gene expression. The data suggests that in vivosublethal damage of tumor cells and activation of src gene are relevant to acquisition of [\mathrm{{H}}_{\scriptscriptstyle{{\mathrm{2}}}}\mathrm{{O}}_{\scriptscriptstyle{\mathrm{2}}}^{\scriptscriptstyle{\mathrm{{CA}}}}+\mathrm{{PGE^{\scriptscriptstyle{{S}}}}}]-phenotype.

Language: English

Document Type: Short communication

Publication date: 2002-08-01