Extracellular matrix components in breast carcinomas

Authors: Kadar A.¹; Toke´s A-M.¹; Kulka J.¹; Robert L.²

Source: Seminars in Cancer Biology, Volume 12, Number 3, June 2002 , pp. 243-257(15)

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Abstract:

A malignant process interferes with the normal ‘programme’ of extracellular matrix biosynthesis and can modify extensively the structure and composition of the matrix. This effect appears to be attributable to several processes such as direct production of some selected matrix macromolecules by malignant cells or indirectly by the production of factors by malignant cells interfering with the regulation of normal matrix production. Other possibilities may also exist, such as the direct action of an environmental carcinogen on otherwise normal mesenchymal cells. The result is a more or less profound modification of tissue structure and composition with possible feedback effects on the malignant process. Some examples will be discussed such as elastin production by some tumours as well as the biosynthesis of some other selected matrix macromolecules as tenascin and osteopontin by breast tumours. Although the detailed mechanisms of these specific matrix productions is not yet completely elucidated, the rapidly increasing knowledge on the regulation of specific matrix production process and deranged matrix production might represent a new area of crosstalk between cancer research and matrix biology.

Language: English

Document Type: Research article

Affiliations: 1: 2nd Department of Pathology, Semmelweis University of Medicine, Ulloi ut 93, 1091 Budapest, Hungary 2: Laboratoire de Recherche en Ophtalmologie, Hoˆtel Dieu, 1 Place du Parvis Notre dame, 75181 Paris cedex 01 et Pavillon Claude Galien, Hoˆpital Limeil Bre´vannes, Universite´ Paris 12, 1 avenue de Verdun, 94456 Limeil Bre´vannes, France

Publication date: 2002-06-01