Chronic B cell malignancies and bone marrow microenvironment

In this: publication
By this: publisher
In this Subject: Biology ,&nbsp; Oncology
By this author: Ghia P. ;&nbsp; Granziero L. ;&nbsp; Chilosi M. ;&nbsp; Caligaris-Cappio F.

Authors: Ghia P.¹; Granziero L.¹; Chilosi M.²; Caligaris-Cappio F.¹

Source: Seminars in Cancer Biology, Volume 12, Number 2, April 2002 , pp. 149-155(7)

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Abstract:

Chronic B-lymphoid malignancies depend upon supportive interactions within specific microenvironments. Follicular lymphoma (FL), chronic lymphocytic leukaemia (CLL) and multiple myeloma (MM) cells accumulate in the bone marrow (BM) where they receive survival or growth signals from by-stander cells. However, they deeply differ in their interaction with the microenvironment. We propose a model where FL and CLL recreate in the BM the microenvironment most suitable to their growth by ‘importing’ the normal cells that usually nurse them in secondary lymphoid organs. In contrast, MM takes advantage of the actual BM microenvironment by ‘instructing’ it through an abnormal activation state. Copyright 2002 Elsevier Science Ltd. All rights reserved.

Language: English

Document Type: Research article

Affiliations: 1: Department of Biomedical Sciences and Human Oncology, University of Torino, Division of Clinical Immunology and Haematology, Ospedale Mauriziano Umberto I , 10060 Candiolo (TO), 10126 Torino and Laboratory of Tumour Immunology, IRCC,, Italy , 10060 Candiolo (TO), 10126 Torino and Laboratory of Tumour Immunology, IRCC,, Italy "> 2: Department of Pathology, University of Verona, Policlinico Borgo Roma, Verona, Italy