Role of activated host T cells in the promotion of MALT lymphoma growth

Author: Guindi M.

Source: Seminars in Cancer Biology, Volume 10, Number 5, October 2000 , pp. 341-344(4)

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Abstract:

Gastric mucosa-associated lymphoid tissue (MALT) B cell lymphomas contain activated helper T cells. The evidence supports the presence of mechanisms of T cell dependence underlying the development of these lymphomas. It appears that the T cells, which activate B cells, may contribute to lymphoma pathogenesis. Co-stimulatory molecules necessary for effective B cell/T cell interaction are expressed in MALT lymphomas. The studies suggest that CD40 signaling, in combination with cytokines, is essential for the development and progression of MALT lymphomas. Activated T cells of low grade gastric MALT lymphoma, while delivering full help to B cells, are apparently deficient in two cytotoxic mechanisms involved in the concomitant control of B cell growth. Copyright 2000 Academic Press

Language: English

Document Type: Research article

Affiliations: Department of Laboratory Medicine, Ottawa Hospital, Civic Site, 1053 Carling Avenue, Ottawa, Ontario, K1Y 4E9, Canada

Publication date: 2000-10-01