Retinoblastoma: the disease, gene and protein provide critical leads to understand cancer

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By this: publisher
In this Subject: Biology ,&nbsp; Oncology
By this author: DiCiommo D. ;&nbsp; Gallie B.L. ;&nbsp; Bremner R.

Authors: DiCiommo D.^{1, 5, 7}; Gallie B.L.^{1, 2, 3, 5, 6}; Bremner R.^{3, 4, 7}

Source: Seminars in Cancer Biology, Volume 10, Number 4, August 2000 , pp. 255-269(15)

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Abstract:

Retinoblastoma has contributed much to the understanding of cancer. The protein product of the RB gene, pRB, is a multifaceted regulator of transcription which controls the cell cycle, differentiation and apoptosis in normal development of specific tissues. Elucidating the mechanisms in which pRB plays a critical role will enable novel therapies and strategies for prevention, not only for retinoblastoma, but for cancer in general. Copyright 2000 Academic Press

Language: English

Document Type: Research article

Affiliations: 1: Departments of Molecular and Medical Genetics 2: Medical Biophysics 3: Ophthalmology 4: Laboratory Medicine and Pathobiology,, University of Toronto 5: Ontario Cancer Institute 6: Hospital for Sick Children 7: Toronto Western Research Institute,, 399 Bathurst Street,, Toronto MST 258, Canada