Gene therapy of cancer with interferon: lessons from tumor models and perspectives for clinical applications

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In this Subject: Biology ,&nbsp; Oncology
By this author: Ferrantini M. ;&nbsp; Belardelli F.

Authors: Ferrantini M.; Belardelli F.

Source: Seminars in Cancer Biology, Volume 10, Number 2, April 2000 , pp. 145-157(13)

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Abstract:

Cytokine gene transfer is a current approach in studies of gene therapy of cancer. IFNs represent valuable cytokines for these studies, since they exert multiple biological effects, including anti-tumor activities. Early studies have been focused on IFN- . Recently, several reports have shown that the transfer of type I IFN (especially IFN- ) genes represents a powerful approach for inducing tumor suppression. Recent studies have underscored new IFN-induced activities on immune cells. This knowledge adds a further rationale for the use of IFN- in strategies of gene therapy of cancer and can be exploited for the design of more selective and effective anticancer treatments.Copyright 2000 Academic Press