Rel/NF-kappaB and IkappaB proteins: an overview

Authors: May M.J.; Ghosh S.

Source: Seminars in Cancer Biology, Volume 8, Number 2, April 1997 , pp. 63-73(11)

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Abstract:

Rel/NF-kappaB proteins constitute a family of structurally-related transcription factors that are regulated by interaction with a family of regulatory proteins, the IkappaB proteins. In this review, we will familiarize the reader with the known Rel/NF-kappaB and IkappaB molecules, and will discuss the types of interactions that occur between these proteins to regulate their function. In addition, we will describe what is known about the structure of Rel/NF-kappaB transcription complexes on DNA. Lastly, we will discuss the wide variety of biological stimuli and conditions which activate NF-kappaB and the genes whose expression are regulated by this family of transcription factors.

Keywords: IkappaB; NF-kappaB; Rel proteins; transcription factors; DNA-binding proteins

Language: English

Document Type: Research article

Affiliations: Section of Immunobiology and Department of Molecular Biophysics and Biochemistry, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT, 06520, USA

Publication date: 1997-04-01